![]() ![]() ![]() "In active fibrogenesis, an active pool of allysine would be generated, but in stable disease or with therapeutic invention, these allysine moieties would be converted to cross-links," the authors reasoned. The probe was developed to target allysine, an amino acid indicative of active collagen cross-linking. They have created a functionalized gadolinium chelate as a probe for magnetic resonance imaging (MRI). To monitor this process, Peter Caravan and collaborators from Massachusetts General Hospital and Harvard Medical School, USA, sought a molecular probe that could specifically recognize the components involved in fibrogenesis. On a molecular level, fibrogenesis is the accumulation and then remodeling of collagen, mainly by cross-linking, to create more rigid and tight structures. If the injury is large or if the tissue is repeatedly damaged, the wound healing process may not be complete, resulting in scar formation that threatens the loss of function and even organ failure. ![]() In normal healing, the fibrous material is eventually replaced by normal tissue. Natural wound healing and tissue injury involves the formation of collagen-based fibrous tissue to close the wound. ![]()
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